New publication “Dynamics and Microbiome Crosstalk: Matrix Metalloproteinases as Key Players in Disease and Therapy”
Matrix metalloproteinases (MMPs) are key enzymes involved in extracellular matrix (ECM) remodeling, regulating a wide range of cellular and immune processes in both homeostatic and pathological conditions. Host–microbiota interactions play a critical role in maintaining ECM balance; however, during dysbiosis, this regulation is disrupted, leading to compromised barrier integrity, pathogen translocation into circulation, and the […]
Recent publication “Allosteric Anti-KLK4 Antibody Development for Targeted Anti-cancer Effects in Ovarian Carcinoma” in JMB
Our team has developed a highly specific monoclonal antibody targeting an allosteric region of KLK4, a serine protease implicated in ovarian carcinoma progression. By combining structural biology, innovative immunization strategies, and computational modeling, we identified and characterized an antibody (ABS4) that not only effectively inhibits KLK4’s enzymatic activity but also significantly reduces proliferation and migration […]
We are hiring!
You can apply here –> https://www.elke.uoa.gr/Prokirikseis_Apasxolisis/Details/8683 We are looking for a motivated Postdoctoral researcher to join our lab. Our lab focuses on defining the nutrition impact on extracellular matrix (ECM) remodeling and microbiome in health and diseases. Microbiome is considered to have fundamental role in efficiency of anti-cancer therapeutic strategies. Food-derived ingredients modulate microbiome […]
Interview to Tpress WEB TV
As part of Tpress WEB TV’s T-PRESS EXPOS show, Assistant Professor Nikolaos Afratis discussed with Katerina Ladopoulos the purpose and goals of the Department of Agricultural Development, Agri-Food, and Natural Resource Management at the National and Kapodistrian University of Athens, along with the education and research activities of the Department.
New Funding
Our research group has been awarded funding from the Hellenic Foundation for Research & Innovation for the research program titled “The Impact of Food-Derived MicroRNAs (xenomiRs) in Extracellular Matrix Remodeling and Microbiota During Malignant Melanoma.” The allocated budget for this program is €169,150.00, covering the period from 2023 to 2025.
Open Positions
We are looking for a motivated Postdoctoral researcher and a PhD candidate to join our lab. Our lab focuses on defining the nutrition impact on extracellular matrix (ECM) remodeling and microbiome in health and diseases. Microbiome is considered to have fundamental role in efficiency of anti-cancer therapeutic strategies. Food-derived ingredients modulate microbiome and ECM deposition […]
