# Matrixbiomelab

> Discover how MatrixBiome Lab explores the impact of nutrition and the microbiome on extracellular matrix remodeling in health, disease, and therapy\.

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## Pages
- [HOME](https://matrixbiomelab.gr/)
- [LAB MEMBERS](https://matrixbiomelab.gr/lab-members/)
- [Publications](https://matrixbiomelab.gr/publications/)
- [RESEARCH](https://matrixbiomelab.gr/research/)
- [NEWS](https://matrixbiomelab.gr/news/)

## Posts
- [Lab Research Highlighted in Nature Reviews Drug Discovery](https://matrixbiomelab.gr/lab-research-highlighted-in-nature-reviews-drug-discovery/)
- [Με επιτυχία ολοκληρώθηκε η επιστημονική ημερίδα με τίτλο «Η επίδραση των microRNAs που προέρχονται από τρόφιμα στο μελάνωμα»](https://matrixbiomelab.gr/με-επιτυχια-ολοκληρωθηκε-η-επιστημον/)
- [ΗΜΕΡΙΔΑ "Η ΕΠΙΔΡΑΣΗ ΤΩΝ microRNAs ΠΟΥ ΠΡΟΕΡΧΟΝΤΑΙ ΑΠΟ ΤΡΟΦΙΜΑ ΣΤΟ ΜΕΛΑΝΩΜΑ](https://matrixbiomelab.gr/ημεριδα-η-επιδραση-των-micrornas-που-προερχον/)
- [New publication in Science Translational Medicine](https://matrixbiomelab.gr/new-publication-in-science-translational-medicine/)

## Publications
- [Biselective remodeling of the melanoma tumor microenvironment prevents metastasis and enhances immune activation in mouse models](https://matrixbiomelab.gr/publication/biselective-remodeling-of-the-melanoma-tumor-microenvironment-prevents-metastasis-and-enhances-immune-activation-in-mouse-models/)
- [Ioannou P, Katsoulieris E, Afratis NA\. Matrix Dynamics and Microbiome Crosstalk: Matrix Metalloproteinases as Key Players in Disease and Therapy\.  Int J Mol Sci\. 2025 Apr 11;26\(8\):3621\. doi: 10\.3390/ijms26083621\.](https://matrixbiomelab.gr/publication/matrix-dynamics-and-microbiome-crosstalk-matrix-metalloproteinases-as-key-players-in-disease-and-therapy-ioannou-p-katsoulieris-e-afratis-na-int-j-mol-sci-2025-apr-112683621-doi-10-3390-ij/)
- [Afratis NA, Riley BT, Chandler PG, Buckle AM, Sagi I\. Allosteric Anti\-KLK4 Antibody Development for Targeted Anti\-cancer Effects in Ovarian Carcinoma\. J Mol Biol\. 2025 Mar 26:169101\. doi: 10\.1016/j\.jmb\.2025\.169101](https://matrixbiomelab.gr/publication/allosteric-anti-klk4-antibody-development-for-targeted-anti-cancer-effects-in-ovarian-carcinoma-afratis-na-riley-bt-chandler-pg-buckle-am-sagi-i-j-mol-biol-2025-mar-26169101-doi-10-1016-j-jm/)
- [Krevvata MI, Afratis N, Spiliopoulou A, Malavaki CJ, Kolonitsiou F, Anastassiou E, Karamanos NK\. A modified protocol for isolation and purity evaluation of a staphylococcal acidic polysaccharide by chromatography and capillary electrophoresis\. Biomed Chromatogr\. 25:531\-4\. 2010\. doi: 10\.1002/bmc\.1490\.](https://matrixbiomelab.gr/publication/krevvata-mi-afratis-n-spiliopoulou-a-malavaki-cj-kolonitsiou-f-anastassiou-e-karamanos-nk-a-modified-protocol-for-isolation-and-purity-evaluation-of-a-staphylococcal-acidic-polysaccharide-by-ch/)
- [Skandalis SS, Gialeli C, Afratis N, Aletras A\. J, Tsegenidis T, Theocharis AD, Karamanos NK\. Pharmacological targeting of proteoglycans and metalloproteinases: an emerging aspect in cancer treatment\. Extracellular Matrix: Pathobiology and Signaling, DeGruyter, 2012](https://matrixbiomelab.gr/publication/skandalis-ss-gialeli-c-afratis-n-aletras-a-j-tsegenidis-t-theocharis-ad-karamanos-nk-pharmacological-targeting-of-proteoglycans-and-metalloproteinases-an-emerging-aspect-in-cancer-treatment/)

## Researches
- [Development and biological evaluation of biological drugs](https://matrixbiomelab.gr/research/development-and-biological-evaluation-of-biological-drugs/)
- [Developing engineered microbes for therapeutics and food supplements](https://matrixbiomelab.gr/research/developing-engineered-microbes-for-therapeutics-and-food-supplements/)
- [Nutrition impact on ECM and Microbiome](https://matrixbiomelab.gr/research/nutrition-impact-on-ecm-and-microbiome/)

## Team members
- [Paraskevi Ioannou](https://matrixbiomelab.gr/team-member/paraskevi-ioannou/)
- [Sylvia Mangani](https://matrixbiomelab.gr/team-member/sylvia-mangani/)
- [Nikolaos Afratis](https://matrixbiomelab.gr/team-member/nikos-afratis/)

## Categories
- [Peer\-review journals](https://matrixbiomelab.gr/category/peer-review-journals/)
- [General](https://matrixbiomelab.gr/category/general/)
- [Book Chapter](https://matrixbiomelab.gr/category/book-chapter/)

## Optional
- [Sitemap index](https://matrixbiomelab.gr/sitemap_index.xml)