Publications
Peer-review journals
Klepfish M, Gross T, Vugman M, Afratis NA, Havusha-Laufer S, Brazowski E, Solomonov I, Varol C, Sagi I. LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis. Front Immunol. 2020 Mar 31; 11:480. doi: 10.3389/fimmu.2020.00480.
Afratis NA, Sagi I. Novel Approaches for Extracellular Matrix Targeting in Disease Treatment. Methods Mol Biol. 1952:261-275. 2019. doi: 10.1007/978-1-4939-9133-4_21
Afratis NA, Klepfish M, Karamanos N.K and Sagi I. The Apparent Competitive Action of ECM Proteases and Cross-Linking Enzymes During Fibrosis: Applications to Drug Discovery. Adv Drug Deliv Rev. 129:4-15. 2018. doi: 10.1016/j.addr.2018.03.004.
Afratis NA, Selman M, Pardo A, Sagi I. Emerging insights into the role of matrix metalloproteases as therapeutic targets in fibrosis. Matrix Biol. 68-69:167-179. 2018. doi: 10.1016/j.matbio.2018.02.007.
Afratis N, Bouris P, Skandalis S.S, Multhaupt H.A, Couchman J.R, Theocharis A.D and Karamanos N.K. IGF-IR regulates the aggressiveness of breast cancer cells via transformation of ECM molecules. Sci Rep. 7:40138. 2017. doi: 10.1038/srep40138.
Afratis N, Nikitovic-Tzanakaki D, Multhaupt H.A, Theocharis A.D, Couchman J.R and Karamanos N.K. Syndecans: key regulators of cell signaling and biological functions. FEBS J. 284:27-41. 2016. doi: 10.1111/febs.13940.
Book Chapter
Afratis NA, Sagi I. Novel Approaches for Extracellular Matrix Targeting in Disease Treatment. Methods in Molecular Biology, 2019.
Asimakopoulou AP, Malavaki C, Afratis NA, Theocharis AD, Lamari FN, Karamanos NK. Validated capillary electrophoretic assays for disaccharide composition analysis of galactosaminoglycans in biologic samples and drugs/nutraceuticals. Methods in Molecular Biology, 2015.
Skandalis SS, Gialeli C, Afratis N, Aletras A. J, Tsegenidis T, Theocharis AD, Karamanos NK. Pharmacological targeting of proteoglycans and metalloproteinases: an emerging aspect in cancer treatment. Extracellular Matrix: Pathobiology and Signaling, DeGruyter, 2012
